Which opioid antagonist has a longer duration of action than naloxone?

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Multiple Choice

Which opioid antagonist has a longer duration of action than naloxone?

Explanation:
Opioid antagonists come in different lengths of action. Naloxone reverses opioid effects quickly, but its effect wears off relatively soon. There are antagonists with a much longer duration, such as naltrexone, whose receptor blockade can last a day or more. So the statement that there exists an antagonist with a longer duration of action than naloxone is the correct concept. The other ideas—shorter duration, the same duration, or not related to naloxone—don’t fit the known pharmacology.

Opioid antagonists come in different lengths of action. Naloxone reverses opioid effects quickly, but its effect wears off relatively soon. There are antagonists with a much longer duration, such as naltrexone, whose receptor blockade can last a day or more. So the statement that there exists an antagonist with a longer duration of action than naloxone is the correct concept. The other ideas—shorter duration, the same duration, or not related to naloxone—don’t fit the known pharmacology.

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