Type O-negative whole blood contains which antibodies in its plasma?

Type O-negative whole blood contains which antibodies in its plasma?

• A. Anti-A and Anti-B antibodies
• B. Anti-D antibodies
• C. No antibodies
• D. Anti-A only

Answer: (A)

The main idea is that ABO antibodies are naturally occurring in plasma. People with blood type O have anti-A and anti-B antibodies in their plasma because they lack A and B antigens on their own red cells and the immune system recognizes A and B as foreign. In type O-negative whole blood, the red cells do not express A, B, or Rh(D) antigens, but the plasma contains anti-A and anti-B antibodies. Anti-D antibodies are not present unless someone has been sensitized to Rh(D) by prior exposure, so that’s not part of the baseline. No antibodies would be incorrect because there are indeed antibodies present, and anti-A only would omit anti-B.

The main idea is that ABO antibodies are naturally occurring in plasma. People with blood type O have anti-A and anti-B antibodies in their plasma because they lack A and B antigens on their own red cells and the immune system recognizes A and B as foreign. In type O-negative whole blood, the red cells do not express A, B, or Rh(D) antigens, but the plasma contains anti-A and anti-B antibodies. Anti-D antibodies are not present unless someone has been sensitized to Rh(D) by prior exposure, so that’s not part of the baseline. No antibodies would be incorrect because there are indeed antibodies present, and anti-A only would omit anti-B.