Postanesthetic shivering can be treated with all of the following EXCEPT:

Postanesthetic shivering can be treated with all of the following EXCEPT:

• A. Meperidine
• B. Physostigmine
• C. Magnesium sulfate
• D. Naloxone

Answer: (D)

Postanesthetic shivering is managed by agents that blunt the central thermoregulatory response and reduce the shivering drive through different mechanisms. Meperidine is a classic option because it has a unique anti-shivering effect beyond simple analgesia, thought to involve modulation of central thermoregulatory pathways through opioid receptors. Magnesium sulfate helps by blocking NMDA receptors, which dampens neural excitability and lowers the shivering drive. Physostigmine, a cholinesterase inhibitor, increases central acetylcholine and can influence thermoregulatory control, with reports of reducing shivering in some settings. Naloxone, however, does not address the thermoregulatory mechanism of shivering; it reverses opioid effects and can worsen pain or agitation, and there is no reliable anti-shivering benefit from reversing opioids.

Postanesthetic shivering is managed by agents that blunt the central thermoregulatory response and reduce the shivering drive through different mechanisms. Meperidine is a classic option because it has a unique anti-shivering effect beyond simple analgesia, thought to involve modulation of central thermoregulatory pathways through opioid receptors. Magnesium sulfate helps by blocking NMDA receptors, which dampens neural excitability and lowers the shivering drive. Physostigmine, a cholinesterase inhibitor, increases central acetylcholine and can influence thermoregulatory control, with reports of reducing shivering in some settings. Naloxone, however, does not address the thermoregulatory mechanism of shivering; it reverses opioid effects and can worsen pain or agitation, and there is no reliable anti-shivering benefit from reversing opioids.