If naloxone is given to a patient receiving ketorolac for postoperative pain, the most likely result would be?

If naloxone is given to a patient receiving ketorolac for postoperative pain, the most likely result would be?

• A. Bradycardia
• B. Hypotension
• C. Pain
• D. None of the above

Answer: (D)

Naloxone blocks opioid receptors and reverses effects produced by opioids, such as analgesia, respiratory depression, and sometimes bradycardia or hypotension. Ketorolac is an NSAID that relieves pain by inhibiting prostaglandin synthesis, not by acting on opioid receptors. If patient pain is being managed with ketorolac alone, there is no opioid effect to reverse, so giving naloxone would not change the analgesia, nor would it cause opioid-related changes in heart rate or blood pressure. In this scenario, none of the listed effects would be expected; the analgesia and hemodynamics should remain unchanged.

Naloxone blocks opioid receptors and reverses effects produced by opioids, such as analgesia, respiratory depression, and sometimes bradycardia or hypotension. Ketorolac is an NSAID that relieves pain by inhibiting prostaglandin synthesis, not by acting on opioid receptors. If patient pain is being managed with ketorolac alone, there is no opioid effect to reverse, so giving naloxone would not change the analgesia, nor would it cause opioid-related changes in heart rate or blood pressure. In this scenario, none of the listed effects would be expected; the analgesia and hemodynamics should remain unchanged.