Allergic reactions to protamine can occur with each of the following except?

Allergic reactions to protamine can occur with each of the following except?

• A. Diabetes treated with NPH insulin
• B. Diabetes treated with regular insulin
• C. Diabetes treated with PZI insulin
• D. Allergy to seafood

Answer: (B)

Protamine is added to certain insulin preparations to slow absorption and extend duration of action. Allergic reactions to protamine can occur in formulations that contain it, and can also be seen in people with seafood (fish) allergy because protamine is derived from fish, such as salmon. NPH insulin contains protamine, so it can trigger protamine-related allergies. Protamine zinc insulin (PZI) also contains protamine and carries the same risk. Seafood allergy raises the possibility of protamine hypersensitivity due to the fish-derived source. Regular insulin, on the other hand, does not contain protamine, so it is not associated with protamine allergic reactions.

Protamine is added to certain insulin preparations to slow absorption and extend duration of action. Allergic reactions to protamine can occur in formulations that contain it, and can also be seen in people with seafood (fish) allergy because protamine is derived from fish, such as salmon.

NPH insulin contains protamine, so it can trigger protamine-related allergies. Protamine zinc insulin (PZI) also contains protamine and carries the same risk. Seafood allergy raises the possibility of protamine hypersensitivity due to the fish-derived source.

Regular insulin, on the other hand, does not contain protamine, so it is not associated with protamine allergic reactions.