Administration of dantrolene with mannitol is expected to cause which effect?

Administration of dantrolene with mannitol is expected to cause which effect?

• A. Muscle spasticity in the postoperative period
• B. Hypothermia
• C. Cardiac dysrhythmias
• D. Diuresis

Answer: (D)

Dantrolene with mannitol is used to promote diuresis. Dantrolene handles the malignant hyperthermia crisis by blocking calcium release in skeletal muscle, stopping the hypermetabolic state. Mannitol acts as an osmotic diuretic, pulling water into the renal tubules and increasing urine output. In malignant hyperthermia, muscle breakdown can release myoglobin, which threatens the kidneys; giving mannitol helps maintain diuresis to flush out myoglobin and protect renal function. So the expected effect of this combination is increased urine production.

Dantrolene with mannitol is used to promote diuresis. Dantrolene handles the malignant hyperthermia crisis by blocking calcium release in skeletal muscle, stopping the hypermetabolic state. Mannitol acts as an osmotic diuretic, pulling water into the renal tubules and increasing urine output. In malignant hyperthermia, muscle breakdown can release myoglobin, which threatens the kidneys; giving mannitol helps maintain diuresis to flush out myoglobin and protect renal function. So the expected effect of this combination is increased urine production.