15-Methyl PGF2a (carboprost, Hemabate) is administered directly into the myometrium to treat uterine atony. Possible effects include

15-Methyl PGF2a (carboprost, Hemabate) is administered directly into the myometrium to treat uterine atony. Possible effects include

• A. Nausea and vomiting
• B. Bronchospasm
• C. Fever
• D. All of the above

Answer: (D)

Carboprost is a prostaglandin F2 alpha analog used to stimulate strong uterine contractions to control postpartum bleeding from uterine atony. Prostaglandins act on smooth muscle throughout the body, so while the goal is to contract the uterus, they can provoke systemic effects. Nausea and vomiting occur because prostaglandins stimulate the GI tract and trigger emetic pathways. Bronchospasm happens as prostaglandins can constrict bronchial smooth muscle, which is especially a concern in patients with reactive airways. Fever is a known pyrogenic effect of prostaglandins. Because these responses can arise with carboprost, all of the listed effects are possible.

Carboprost is a prostaglandin F2 alpha analog used to stimulate strong uterine contractions to control postpartum bleeding from uterine atony. Prostaglandins act on smooth muscle throughout the body, so while the goal is to contract the uterus, they can provoke systemic effects. Nausea and vomiting occur because prostaglandins stimulate the GI tract and trigger emetic pathways. Bronchospasm happens as prostaglandins can constrict bronchial smooth muscle, which is especially a concern in patients with reactive airways. Fever is a known pyrogenic effect of prostaglandins. Because these responses can arise with carboprost, all of the listed effects are possible.